Contact hypersensitivity and Langerhans cells.

Allergens or antigens when introduced on or in the skin may become localized at the surface of and in Langerhans cells (LCs). Langerhans cells are a strategically situated cell population able to migrate into lymphatics and lymph nodes. During the course of contact allergic reactions, they are apposed to lymphocytes; some LCs are injured by interaction with… (More)