Contact formation during fibroblast locomotion: involvement of membrane ruffles and microtubules

@article{Rinnerthaler1988ContactFD,
  title={Contact formation during fibroblast locomotion: involvement of membrane ruffles and microtubules},
  author={Gottfried Rinnerthaler and Benjamin Geiger and John Victor Small},
  journal={The Journal of Cell Biology},
  year={1988},
  volume={106},
  pages={747 - 760}
}
We have correlated the motility of the leading edge of fibroblasts, monitored by phase-contrast cinematography, with the relative distributions of several cytoskeletal elements (vinculin, tubulin, and actin) as well as with the contact patterns determined by interference reflection microscopy. This analysis has revealed the involvement of both ruffles and microspikes, as well as microtubules in the initiation of focal contact formation. Nascent vinculin sites within the leading edge or at its… CONTINUE READING

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The crawling movement of metazoan cells

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