Contact dermatitis to topical acne drugs: a review of the literature

@article{Foti2015ContactDT,
  title={Contact dermatitis to topical acne drugs: a review of the literature},
  author={Caterina Foti and Paolo Romita and Alessandro Borghi and Gianni D. Angelini and Domenico Bonamonte and Monica Corazza},
  journal={Dermatologic Therapy},
  year={2015},
  volume={28}
}
Acne vulgaris is a chronic dermatological disorder that affects the majority of teenagers in the Western world. Topical therapy is widely used to treat mild‐moderate acne and is known as well‐tolerated thanks to its low systemic toxicity, although associated to skin adverse effects. Acne seems to be associated also to an intrinsic alteration of the epidermal barrier, regarding both the upper and the follicular stratum corneum that promotes the onset of such local side effects. The commonest one… 

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A 22-year-old non-atopic woman presented to the Emergency Unit with a severe erythematous-oedematous eruption on her face associated with severe itching and burning, and was treated with intravenous injections of betamethasone and chlorphenamine maleate.

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Systemic treatment with isotretinoin was stopped, the metallic accessories were removed and the eczematous manifestations healed with moisturizers and topical steroids.

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Common dermatologic diseases can exist concomitantly with Allergic contact dermatitis, many of which can be treated by compounds that precipitate or worsen preexisting ACD.

Contact allergy in children with atopic dermatitis: a retrospective study.

The study highlights the importance of patch testing in atopic children for continuously monitoring the trends and changes of contact allergies that are a common disease and is even significantly increasing for some allergens, as fragrances.

Efficacy and tolerability of short contact therapy with tretinoin, clindamycin, and glycolic acid gel in acne: A randomized, controlled, assessor‐blinded two‐center trial: The MASCOTTE study

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References

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The importance of proper skin care as a component of the management of acne vulgaris is supported by the information that is currently available and the available literature on this subject area is discussed.

Allergic contact dermatitis after isotretinoin treatment for acne

This patient’s contact dermatitis developed following the application of emollients to treat xerosis caused by isotretinoin therapy in an atopic individual.

Allergic contact angioedema to benzoyl peroxide

Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch‐test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.

Allergic contact dermatitis from benzoyl peroxide transferred by a loving son

A 39-year-old woman with a personal history of jewellery intolerance reported episodes of erythemato-vesicular pruritic plaques over her face, especially on the malar areas, for the last 2 months, and a diagnosis of allergic contact dermatitis due to benzoyl peroxide was made.

[Eczema caused by contact allergy to tretinoin].

The case of a 34-year-old man who developed contact dermatitis in areas where a topical tretinoin preparation was applied is reported, and oral administration of isotretin to this patient would carry a risk of systemic complications.

Contact dermatitis due to clindamycin.

  • R. Coskey
  • Medicine, Biology
    Archives of dermatology
  • 1978
A case of contact dermatitis that was due to 1% clindamycin hydrochloride solution is described, which means a 33-year-old woman was seen on March 7, 1977, because of excoriated, pruritic acne lesions that involved her face.

Clinical relevance of skin barrier changes associated with the use of oral isotretinoin: the importance of barrier repair therapy in patient management.

The epidermal barrier impairments that have been associated with oral isotretinoin are reviewed along with clinical implications and strategies to mitigate the altered effects of epidersmal barrier functions are reviewed.

Clinical relevance of skin barrier changes associated with the use of oral isotretinoin: the importance of barrier repair therapy in patient management.

The epidermal barrier impairments that have been associated with oral isotretinoin are reviewed along with clinical implications and strategies to mitigate the altered effects of epidersmal barrier functions are reviewed.

Delayed type hypersensitivity to benzoyl peroxide.

An individual with an incipient edematous reaction to topical BP used for acne therapy is reported here and this under-recognized presentation is discussed in the context of published literature on BP-induced hypersensitivity and irritation.

Allergic contact dermatitis from spironolactone

Tests with the constituents of the cream confirmed an allergic contact reaction to spironolactone, and a 30-year-old woman presented with acute facial dermatitis after the use of Spiroderm® cream for acne vulgaris.
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