Contact dermatitis to topical acne drugs: a review of the literature

  title={Contact dermatitis to topical acne drugs: a review of the literature},
  author={Caterina Foti and Paolo Romita and Alessandro Borghi and Gianni D. Angelini and Domenico Bonamonte and Monica Corazza},
  journal={Dermatologic Therapy},
Acne vulgaris is a chronic dermatological disorder that affects the majority of teenagers in the Western world. Topical therapy is widely used to treat mild‐moderate acne and is known as well‐tolerated thanks to its low systemic toxicity, although associated to skin adverse effects. Acne seems to be associated also to an intrinsic alteration of the epidermal barrier, regarding both the upper and the follicular stratum corneum that promotes the onset of such local side effects. The commonest one… 

Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects

An overview of the main topical antibiotics used in dermatology, focusing on their clinical role in the most common dermatological indications is provided, using MEDLINE and PubMed for pertinent, scientific, and clinical publications until March 2020.

Allergic Contact Dermatitis to Clindamycin and Benzoyl Peroxide Resembling “Urticaria/Angioedema”

  • P. Romita
  • Medicine
    Biomedical Journal of Scientific & Technical Research
  • 2019
A 22-year-old non-atopic woman presented to the Emergency Unit with a severe erythematous-oedematous eruption on her face associated with severe itching and burning, and was treated with intravenous injections of betamethasone and chlorphenamine maleate.

Topical dermocosmetics and acne vulgaris

The aim of this review is to highlight the importance of choosing the most suitable topical dermocosmetics for the different skin types, as well as the most effective timing and method to combine dermOCosmetics with the standard acne treatment.

Short contact therapy with adapalen 0.3%/benzoyl peroxide 2.5% gel for maintenance after systemic isotretinoin treatment

It is proposed that topical retinoids should be recommended, because of their effects on the key factors of acne pathogenesis such as excess sebum production, hyperkeratinization of the pilosebaceous follicles, mixed microbial metabolites promoting inflammation.

Allergic Contact Dermatitis and Concomitant Dermatologic Diseases: A Retrospective Study

Common dermatologic diseases can exist concomitantly with Allergic contact dermatitis, many of which can be treated by compounds that precipitate or worsen preexisting ACD.

Contact allergy in children with atopic dermatitis: a retrospective study.

The study highlights the importance of patch testing in atopic children for continuously monitoring the trends and changes of contact allergies that are a common disease and is even significantly increasing for some allergens, as fragrances.

Efficacy and tolerability of short contact therapy with tretinoin, clindamycin, and glycolic acid gel in acne: A randomized, controlled, assessor‐blinded two‐center trial: The MASCOTTE study

A 2‐center randomized parallel groups, controlled, assessor‐blinded study comparing MP‐gel applied as SCT in comparison with MP‐ gel used as SAT, finding that better clinical efficacy and better tolerability in SCT were significantly higher than in SAT.

Patch Test Reactions Associated With Topical Medications: A Retrospective Analysis of the North American Contact Dermatitis Group Data (2001–2018)

Positive patch test reactions associated with topical medications were common, and most were clinically relevant, and patients with topical medication allergy were twice as likely to have anal/genital involvement.

A Case of a Paediatric Patient With Allergic Contact Dermatitis to Benzoyl Peroxide

A case of a paediatric patient with patch test–confirmed severe allergic contact dermatitis to benzoyl peroxide requiring hospitalisation and systemic treatment is presented.

Allergic contact dermatitis from vitamins: A systematic review

The present review may be helpful to provide an insight into the sensitizing role of at least certain vitamins and may also offer possible patch test alternatives for definitive diagnosis.



Allergic contact dermatitis after isotretinoin treatment for acne

This patient’s contact dermatitis developed following the application of emollients to treat xerosis caused by isotretinoin therapy in an atopic individual.

Allergic contact angioedema to benzoyl peroxide

Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch‐test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.

Allergic contact dermatitis from benzoyl peroxide transferred by a loving son

A 39-year-old woman with a personal history of jewellery intolerance reported episodes of erythemato-vesicular pruritic plaques over her face, especially on the malar areas, for the last 2 months, and a diagnosis of allergic contact dermatitis due to benzoyl peroxide was made.

[Eczema caused by contact allergy to tretinoin].

The case of a 34-year-old man who developed contact dermatitis in areas where a topical tretinoin preparation was applied is reported, and oral administration of isotretin to this patient would carry a risk of systemic complications.

Contact dermatitis due to clindamycin.

  • R. Coskey
  • Medicine, Biology
    Archives of dermatology
  • 1978
A case of contact dermatitis that was due to 1% clindamycin hydrochloride solution is described, which means a 33-year-old woman was seen on March 7, 1977, because of excoriated, pruritic acne lesions that involved her face.

Clinical relevance of skin barrier changes associated with the use of oral isotretinoin: the importance of barrier repair therapy in patient management.

The epidermal barrier impairments that have been associated with oral isotretinoin are reviewed along with clinical implications and strategies to mitigate the altered effects of epidersmal barrier functions are reviewed.

Contact dermatitis in patients with leg ulcers

The incidence of contact allergy to 63 substances, including active principles and excipients used in n variety of topical preparations, has been studied by patch testing in 306 patients being

Allergic contact dermatitis from spironolactone

Tests with the constituents of the cream confirmed an allergic contact reaction to spironolactone, and a 30-year-old woman presented with acute facial dermatitis after the use of Spiroderm® cream for acne vulgaris.

Contact allergy to erythromycin

There was an excellent response to combined oral and topical metronidazole, and oral therapy was stopped on day 20, and the dermatosis gradually cleared within the next month.

Allergic contact dermatitis to topical antibiotics: Epidemiology, responsible allergens, and management.