Contact dermatitis caused by brazilin in Caesalpinia sappan

@article{Xu2015ContactDC,
  title={Contact dermatitis caused by brazilin in Caesalpinia sappan},
  author={Yingyang Xu and Jia Yin},
  journal={Contact Dermatitis},
  year={2015},
  volume={73}
}
A 49-year-old woman presented with an eczematous reaction on her hands that which had appeared 5 days previously. To treat her wrist sprain, she had applied hot compresses with a herbal water decoction of multi-ingredient formulations on her hands for half an hour, and bathed her hands in this decoction for another 20 min. After 1 day, her hands became erythematous, with burning and itching (Fig. 1a, b). The ingredients of the decoction are Caesalpinia sappan, myrrh, Crocus sativus L., and… 
3 Citations

References

SHOWING 1-4 OF 4 REFERENCES
A patch test study of 27 crude drugs commonly used in Chinese topical medicaments
TLDR
Reducing the concentration and simplifying the compositions of these components, as well as replacement with those of low allergenicity in CTM, such as Rhizoma Arisaematis, Herba Lycopodii, Radix Cyathulae Officinalis, and Stigmata Croci may be advocated.
Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products – part 1: Achillea millefolium–Curcuma longa
This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the
Brazilin Isolated from Caesalpinia sappan Suppresses Nuclear Envelope Reassembly by Inhibiting Barrier-to-Autointegration Factor Phosphorylation
TLDR
It is proposed that brazilin isolated from C. sappan may be a new anticancer drug candidate that induces cell death by inhibiting vaccinia-related kinase 1–mediated BAF phosphorylation.
Chinese Pharmacopoeia Commission