Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB.

@article{Aoki2008ContactdependentGI,
  title={Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB.},
  author={Stephanie K. Aoki and Juliana C. Malinverni and Kyle Jacoby and Benjamin Thomas and Rupinderjit Pamma and Brooke N Trinh and Susan Remers and Julia S. Webb and Bruce Albert Braaten and Thomas J Silhavy and David A. Low},
  journal={Molecular microbiology},
  year={2008},
  volume={70 2},
  pages={323-40}
}
Contact-dependent growth inhibition (CDI) is a phenomenon by which bacterial cell growth is regulated by direct cell-to-cell contact via the CdiA/CdiB two-partner secretion system. Characterization of mutants resistant to CDI allowed us to identify BamA (YaeT) as the outer membrane receptor for CDI and AcrB as a potential downstream target. Notably, both BamA and AcrB are part of distinct multi-component machines. The Bam machine assembles outer membrane beta-barrel proteins into the outer… CONTINUE READING
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