Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis.

  title={Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis.},
  author={John N. Krieger and Jonathan I Ravdin and Michael F. Rein},
  journal={Infection and immunity},
  volume={50 3},
The cytopathogenic mechanisms of Trichomonas vaginalis have been debated since the 1940s. We examined the following three proposed pathogenic mechanisms: contact-dependent extracellular killing, cytophagocytosis, and extracellular cytotoxins. Serial observations of Chinese hamster ovary (CHO) cell monolayers exposed to trichomonads revealed that (i) trichomonads form clumps, (ii) the clumps adhere to cells in culture, and (iii) monolayer destruction occurs only in areas of contact with T… CONTINUE READING
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