Contact allergy to the preservative Kathon® CG

@article{Bjrkner1986ContactAT,
  title={Contact allergy to the preservative Kathon{\textregistered} CG},
  author={Bert Bj{\"o}rkner and Magnus Bruze and Inger Dahlquist and Sigfried Fregert and Birgitta Gruvberger and K Persson},
  journal={Contact Dermatitis},
  year={1986},
  volume={14}
}
Of 976 patients routinely patch tested with Kathon® CG (Rohm & Haas), 300 ppm. 43 (4.4%) gave a positive reaction. Of 170 patients routinely tested with Kathon® CG 250 ppm, 10 (5.9%) gave a positive reaction. Out of 34 patients tested with serial dilution of Kathon® CG, 17 (50%) reacted to to 100 ppm, 8 to 30 ppm and 2 to 10 ppm. The concentration of 1000 ppm of Rathon® CG was irritant in some cases, but 300 ppm was not irritant. 
Patch test sensitivity to the preservative Kathon CG in Spain
TLDR
From November 1988 to June 1989, patch tested 626 unselected contact dermatitis patients with Kathon CG solution containing 200 ppm active ingredients and obtained 22 positive reactions, with women predominantly sensitized, the principal source of sensitization being cosmetics. Expand
Rapid increase in contact allergy to Kathon® CG in Finland
TLDR
The cause of the rapid increase of Kathon® CG allergy in Finland during the winter of 1985–1986 was the use of a popular moisturizing cream containing first 19 ppm, then 7 ppm of a mixture of 2 isothiazolinones (Euxyl® K 100). Expand
Sensitization to Kathon CG in Switzerland: Report of the Swiss Contact Dermatitis Research Group
TLDR
In about one-third of the authors' patients, relevance could be confirmed clinically by the disappearance of dermatitis when the use of Kathon-containing creams was discontinued, by a positive patch test reaction with the K Marathon-containing cosmetic, or (in Geneva) by threshold patch testing. Expand
Demonstration of Kathon® CG in some commercial products
TLDR
There were no differences between “leave on” and “rinse off” products concerning the relative number of products containing Kathon® CG and the concentrations of the preservative. Expand
Frequency of sensitisation to the preservative Kathon® CG
TLDR
The incidences of sensitisation to Kathon® CG are reported for patients routinely tested from 1984 to 1986 in Bari, Louvain, Nijmegen, Oulu and San Francisco, and for men from 1.4% in Oulu to 0% in San Francisco. Expand
Contact allergy to the active ingredients of Kathon® CG
TLDR
The preservative Kathon1 CG is a commercial preparation, consisting of 2 active ingredients and other components, and patch testing was performed with serial dilutions, and with 5 chromatographically separated fractions. Expand
Contact allergy to the preservative Kathon CG
TLDR
With the rising incidence of Kathon CG sensitivity, dermatologists, pharmacists and the cosmetics industry should be alert to the potential problems of this preservative, even when used at the recommended concentration. Expand
Epicutaneous patch test with the preservative Kathon® CG
TLDR
There is evidence that the hydrazine content of the gold-plating baths caused the patients' dermatitis and the importance of good skin protection in workers dealing withHydrazine and its derivates is pointed out. Expand
Mercurochrome‐induced allergic contact dermatitis
TLDR
A wrongly diluted patch test preparation of Kathon CG negatively influenced the test results in Austria for years and the conclusion: never trust product labels too much or for too long. Expand
Sensitivity to Kathon CG: findings in 365 consecutive patients
In the period from 1983 through 1986, 365 consecutive patients suspected as having allergic contact dermatitis were tested for reaction to Kathon CG. This test was positive in 20 of these patientsExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 11 REFERENCES
Kathon® CG: cosmetic allergy and patch test sensitization
TLDR
These appear to be the first case reports of non‐occupational sensitization to Kathon CG, a preservative for cosmetics and toiletries containing, as active ingredients, 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one. Expand
Patch tests with fragrance materials and preservatives
TLDR
Patients suspected of cosmetic allergy were patch tested with a series of 16 fragrance materials and 9 preservatives and for more of these substances gave positive reactions, the largest numbers of positive patch test reactions were seen to isocugenol, oak moss, geraniol, α‐amylcinnamic alcohol, and a mixture of α-amyl cinnamic aldehyde. Expand
Kathon biocide: manifestation of delayed contact dermatitis in guinea pigs is dependent on the concentration for induction and challenge.
TLDR
The data demonstrate that for Kathon biocide, there is an induction/elicitation concentration dependency for delayed contact dermatitis response, and there is a "no response concentration" zone where the biocide can be used without concern for clinically significant delayedContact dermatitis. Expand
Publication of allergens
TLDR
Tap water from Copenhagen and its suburbs was screened with an electrochemical analytical method known as chelate adsorption voltametry, and the results clearly show that the nickel content in the samples in general is below 1 f.l.g.g/l. Expand
Doseresponse assessments of Kathon® biocide
  • Contact Dermatitis 1985:
  • 1985
Doseresponse assessments of Kathon® biocide. Contact Dermatitis
  • 1985
Allergisches Kontaktekzema durch Isothiazolin3-on-Derivate
  • Derm Beruf Umwelt
  • 1984
3-isothiazolones. United States Patent 3,761
    Demonstration of the preservative Kathon ® CG in commercial products , ( to be published )
      ...
      1
      2
      ...