Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay.

@article{Zhu2014ContactAO,
  title={Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay.},
  author={Shu Zhu and Scott L. Diamond},
  journal={Thrombosis research},
  year={2014},
  volume={134 6},
  pages={1335-43}
}
Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a patterned kaolin (0 to 0.3 pg/μm(2))/type 1 collagen fibril surface for controlled microfluidic clotting assays. Perfusion of whole blood (treated only with a low level of 4 μg/mL of the XIIa inhibitor, corn… CONTINUE READING