Contact-activated migration of melanoma B16 and sarcoma XC cells.

  title={Contact-activated migration of melanoma B16 and sarcoma XC cells.},
  author={Zbigniew Madeja and Iwona Szymkiewicz and Anna Żaczek and Jolanta Sroka and Katarzyna Miękus and Włodzimierz Korohoda},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={79 4},
During migration, tumour cells interact with neighbouring neoplastic and normal host cells, and such interaction may influence their motile activity. We investigated the effect of homotypic collisions on the motile activity of two tumour cell lines, mouse melanoma B16 and rat sarcoma XC, and nontransformed human skin fibroblasts. It was found that the tumour cells show only limited motile activity when moving as single cells without contact with neighbours. At a higher density of the culture… CONTINUE READING

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