Contact Mechanics of a Small Icosahedral Virus.

@article{Zeng2017ContactMO,
  title={Contact Mechanics of a Small Icosahedral Virus.},
  author={Cheng Zeng and Mercedes Hernando-P{\'e}rez and Bogdan Dragnea and Xiang Ma and Paul van der Schoot and Roya Zandi},
  journal={Physical review letters},
  year={2017},
  volume={119 3},
  pages={
          038102
        }
}
A virus binding to a surface causes stress of the virus cage near the contact area. Here, we investigate the potential role of substrate-induced structural perturbation in the mechanical response of virus particles to adsorption. This is particularly relevant to the broad category of viruses stabilized by weak noncovalent interactions. We utilize atomic force microscopy to measure height distributions of the brome mosaic virus upon adsorption from solution on atomically flat substrates and… 
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References

SHOWING 1-10 OF 32 REFERENCES

How to perform a nanoindentation experiment on a virus.

  • W. Roos
  • Materials Science
    Methods in molecular biology
  • 2011
The experimental procedures for viral nanoindentation experiments are described here in detail, focusing on surface preparation, AFM imaging and nanoindenteration, and the subsequent data analysis of the force-distance curves.

Contact, Adhesion and Rupture of Elastic Solids

1 Elements of Surface Physics.- 2 Elements of Elasticity.- 3 Rupture and Adherence of Elastic Solids.- 4 Frictionless Elastic Contact.- 5 Study of Some Geometries.- Appendix A.- References.- Appendix…

Intermolecular And Surface Forces

Contact

I consider myself very fortunate for having worked at Professor Heisenberg’s lab, and I particularly admire his capacity to deal with the most elusive questions in depth and his ability to obtain the best from every member of the lab team for the benefit of all and for the scientific breakthroughs.

Principles of virology

The past five years have seen several new emergences and spillover events; some significant yet unnoticed by the general public, according to Fenner's Veterinary Virology.

THEORY OF ELASTICITY

Soft Matter

Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms & Conditions and the Ethical guidelines still apply.…

IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A

入侵病原体与宿主之间呈动态平衡，以维持病原体成功地寄生在宿主体内而不致宿主死亡，这是许多寄生虫感染的一个重要特征。包括曼氏血吸虫在内的许多蠕虫感染中，持续的炎症反应比病原体本身对宿主的危害更大，降低宿主的免疫反应具有重要意义。曼氏血吸虫感染后，宿主活化CD4^＋Th2细胞，分泌IL-4、IL-5和IL-13。最近研究表明IL-13是肝组织纤维化的重要调节因子。

Methods Mol

  • Biol. 783, 251
  • 2011

Retrovirology 10

  • 4
  • 2013