Contact Lens Sensors in Ocular Diagnostics

  title={Contact Lens Sensors in Ocular Diagnostics},
  author={Nicholas M. Farandos and Ali Kemal Yetisen and Michael J. Monteiro and Christopher R. Lowe and Seok Hyun Yun},
  journal={Advanced Healthcare Materials},
Contact lenses as a minimally invasive platform for diagnostics and drug delivery have emerged in recent years. Contact lens sensors have been developed for analyzing the glucose composition of tears as a surrogate for blood glucose monitoring and for the diagnosis of glaucoma by measuring intraocular pressure. However, the eye offers a wider diagnostic potential as a sensing site and therefore contact lens sensors have the potential to improve the diagnosis and treatment of many diseases and… 

Ophthalmic Sensors and Drug Delivery

The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed, and the potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery Systems are discussed.

Structurally coloured contact lens sensor for point-of-care ophthalmic health monitoring.

A structurally coloured contact lens sensor with a tunable colour is established, which can directly report changes in moisture and pressure that are critical signs for xerophthalmia and glaucoma diagnosis, respectively, by altering colours.

Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

A multifunctional contact lens sensor that can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses is developed.

Fluorescence Sensing Technologies for Ophthalmic Diagnosis

This review summarizes the applied ophthalmic fluorescence sensing technologies in tears for ocular diagnosis and monitoring and the cooperation of fabricated fluorescent sensor with mobile phone readout devices for diagnosing ocular diseases with specific biomarkers continuously is discussed.

Multifunctional flexible contact lens for eye health monitoring using inorganic magnetic oxide nanosheets

This work developed a flexible multifunctional contact lens based on inorganic γ-Fe 2 O 3 @NiO magnetic oxide nanosheets, which can be attached conformally and seamlessly to the eyeball to simultaneously monitor glucose level in tears, eyeball movement, and intraocular pressure.

A Review Study on Monitoring of Physiological Parameters for Ocular Diagnostics and Administering Drugs for Ocular Diseases through a Contact Lens (A Wearable Device)

Soft contact lenses can be used to diagnose specific disorders as well as deliver medications, which have advantages over traditional eye drops in terms of prolonged residence duration and ocular bioavailability.

Flexible, wearable microfluidic contact lens with capillary networks for tear diagnostics

Wearable contact lenses attract great interest as a minimally invasive diagnostic platform. With advances in biomaterials, electronics and microfabrication, contact lenses offer the potential to

Ophthalmic sensing technologies for ocular disease diagnostics.

This review will summarize the applied ophthalmic technologies for ocular diagnostics and tear monitoring, including both conventional and biosensing technologies, plus targeted biomarkers for the convenience of diagnosis of various ocular diseases.

CLEAR - Contact lens technologies of the future.

  • L. JonesAlex Hui M. Willcox
  • Medicine
    Contact lens & anterior eye : the journal of the British Contact Lens Association
  • 2021



Fibre optics sensors in tear electrolyte analysis: towards a novel point of care potassium sensor.

Clinical trial of a noninvasive contact lens glucose sensor.

The contact lens glucose sensor shows promise as a home glucose monitor in patients with diabetes and was comfortable and were tolerated well, even in patients who had not previously worn contact lenses.

Initial clinical testing of a holographic non-invasive contact lens glucose sensor.

The holographic contact lens glucose sensor shows promise as a non-invasive home glucose monitor and appeared to track blood glucose well.

Flexible Three-Dimensional Electrochemical Glucose Sensor with Improved Sensitivity Realized in Hybrid Polymer Microelectromechanical Systems Technique

The proposed flexible glucose sensors with 3-D microstructure electrodes are more sensitive to lower glucose concentrations and generate higher current signal than conventional glucose sensors.

Therapeutic uses of contact lenses.