Contact Lens Sensors in Ocular Diagnostics

  title={Contact Lens Sensors in Ocular Diagnostics},
  author={Nicholas M. Farandos and Ali Kemal Yetisen and Michael J. Monteiro and Christopher R. Lowe and Seok Hyun Yun},
  journal={Advanced Healthcare Materials},
Contact lenses as a minimally invasive platform for diagnostics and drug delivery have emerged in recent years. Contact lens sensors have been developed for analyzing the glucose composition of tears as a surrogate for blood glucose monitoring and for the diagnosis of glaucoma by measuring intraocular pressure. However, the eye offers a wider diagnostic potential as a sensing site and therefore contact lens sensors have the potential to improve the diagnosis and treatment of many diseases and… 
Ophthalmic Sensors and Drug Delivery
The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed, and the potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery Systems are discussed.
Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics
A multifunctional contact lens sensor that can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses is developed.
Fluorescence Sensing Technologies for Ophthalmic Diagnosis
This review summarizes the applied ophthalmic fluorescence sensing technologies in tears for ocular diagnosis and monitoring and the cooperation of fabricated fluorescent sensor with mobile phone readout devices for diagnosing ocular diseases with specific biomarkers continuously is discussed.
Multifunctional flexible contact lens for eye health monitoring using inorganic magnetic oxide nanosheets
This work developed a flexible multifunctional contact lens based on inorganic γ-Fe 2 O 3 @NiO magnetic oxide nanosheets, which can be attached conformally and seamlessly to the eyeball to simultaneously monitor glucose level in tears, eyeball movement, and intraocular pressure.
Flexible, wearable microfluidic contact lens with capillary networks for tear diagnostics
Wearable contact lenses attract great interest as a minimally invasive diagnostic platform. With advances in biomaterials, electronics and microfabrication, contact lenses offer the potential to
Ophthalmic sensing technologies for ocular disease diagnostics.
This review will summarize the applied ophthalmic technologies for ocular diagnostics and tear monitoring, including both conventional and biosensing technologies, plus targeted biomarkers for the convenience of diagnosis of various ocular diseases.
CLEAR - Contact lens technologies of the future.
  • L. JonesAlex Hui M. Willcox
  • Medicine
    Contact lens & anterior eye : the journal of the British Contact Lens Association
  • 2021
Smart Contact Lenses for Biosensing Applications
The state‐of‐the‐art design and fabrication of smart contact lenses for biomedical applications, including contact lens materials, fabrication technologies, and integration, are presented and biosensors implemented in contact lenses to measure lactic acid, glucose, intraocular pressure, and other key metabolites in tears are highlighted.
Microfluidic Contact Lenses
A microlithography method is developed to fabricate microconcavities and microchannels in a hydrogel‐based contact lens via a combination of laser patterning and embedded templating.


Fibre optics sensors in tear electrolyte analysis: towards a novel point of care potassium sensor.
Fluorescent measurement in the non-invasive contact lens glucose sensor.
The biwavelength contact lens glucose sensor shows promise as a non-invasive home glucose monitor.
Flexible Three-Dimensional Electrochemical Glucose Sensor with Improved Sensitivity Realized in Hybrid Polymer Microelectromechanical Systems Technique
The proposed flexible glucose sensors with 3-D microstructure electrodes are more sensitive to lower glucose concentrations and generate higher current signal than conventional glucose sensors.
Therapeutic uses of contact lenses.
Reusable, robust, and accurate laser-generated photonic nanosensor.
A clinically relevant optical glucose nanosensor that can be reused at least 400 times without a compromise in accuracy permits diagnosis of glucosuria in the urine samples of diabetic patients with an improved performance compared to commercial high-throughput urinalysis devices.