ContaMiner and ContaBase: a webserver and database for early identification of unwantedly crystallized protein contaminants

Abstract

Solving the phase problem in protein X-ray crystallography relies heavily on the identity of the crystallized protein, especially when molecular replacement (MR) methods are used. Yet, it is not uncommon that a contaminant crystallizes instead of the protein of interest. Such contaminants may be proteins from the expression host organism, protein fusion… (More)

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