Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer

@inproceedings{Cook2012ConsumptionOO,
  title={Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer},
  author={Cody C Cook and Ara Kim and Shuji Terao and Akinobu Gotoh and Masahiro Higuchi},
  booktitle={Cell Death and Disease},
  year={2012}
}
Changes in mitochondrial genome such as mutation, deletion and depletion are common in cancer and can determine advanced phenotype of cancer; however, detailed mechanisms have not been elucidated. We observed that loss of mitochondrial genome reversibly induced overexpression and activation of proto-oncogenic Ras, especially K-Ras 4A, responsible for the… CONTINUE READING