Consultation on assessment of the health risk of dioxins; re-evaluation of the tolerable daily intake (TDI): Executive Summary

  title={Consultation on assessment of the health risk of dioxins; re-evaluation of the tolerable daily intake (TDI): Executive Summary},
  author={John Christian Larsen},
  journal={Food Additives \& Contaminants},
  pages={223 - 240}
  • J. Larsen
  • Published 1 April 2000
  • Chemistry, Biology
  • Food Additives & Contaminants
Polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) constitute a group of persistent environmental chemicals. A number of dioxin or furan congeners, as well as some co-planar PCBs have been shown to exert a number of toxic responses similar to those of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin. These e€ ects include dermal toxicity, immunotoxicity, reproductive e€ ects and teratogenicity, endocrine disruption… 

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Overall, the findings indicate that swordfish consumption poses a risk to the Algerian consumer.

Dietary intake of dioxins in Japan in 2016 with time trends since 1998

  • T. TsutsumiR. Matsuda H. Akiyama
  • Medicine, Environmental Science
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
  • 2018
Overall, the average dioxin intake appeared to be decreasing gradually during the period of study, and the latest average intake was the lowest since 1998 and was about one-third of the average intake in 1998.

Exposure and risk assessment of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) for primiparous mothers and breastfed infants in Penang, Malaysia

Levels in breast milk were significantly correlated with years of residence at potential contaminated site, demonstrating the exposure risk to infants, especially from Penang region, to these pollutants from human milk intake are potentially high during the lactation period.

Levels and trends of PCDD/Fs and DL-PCBs in Polish animal feeds, 2004–2017

It can be concluded that concentrations of PCDD/Fs and DL-PCBs in Polish feed materials were sufficiently low to ensure low concentrations in animal-derived products.

Polychlorinated dioxins, furans (PCDD/Fs) and dioxin‐like polychlorinated biphenyls (dl‐PCBs) in food from Italy: Estimates of dietaryintake and assessment

Ccinogenicity risk results revealed that highly exposed individuals were distributed over all sex/age groups, even though the proportion of individuals exceeding the safe limit was higher in children, and the importance of trying to control the levels of these contaminants in fishery products, particularly in fish, who represents one of the main exposure sources for consumers.

Comparative evaluation of xenobiotics in human and dietary milk: persistent organic pollutants and mycotoxins.

It is made clear that the presence of dioxins and persistent organic pollutants in human milk is not an indication for avoiding breastfeeding, and the beneficial effect of breastfeeding as the optimal food source for newborn babies should not be disregarded.



Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife.

It was concluded that the TEF concept is still the most plausible and feasible approach for risk assessment of halogenated aromatic hydrocarbons with dioxinlike properties.

In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans hooded rat offspring.

Administration of TCDD at dosage levels of 0.2, 0.8, and 1.0 microg/kg produces morphological reproductive alterations in female rat offspring as a consequence of in utero exposure, and these effects did not appear to result from abnormal ovarian function during prepubertal development.

Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

This 15-year study indicates that latent female reproductive abnormalities may be associated with dioxin exposure in the rhesus and the effects of this toxin may be more diverse than previously recognized.

1997b, In utero exposure to low doses of 2,3,7,8-tetrac hlorodibenzo-p-dioxin (TCDD ) alters reproductive development of female Long Evans hooded rat

  • o€ spring. Toxicology and Applied Pharmacology,
  • 1997

A dose-response analysis of the reproductive e ects of a single gestational dose of 2,3,7,8-tetra c hlorodibenzo-p-dioxin (TCDD) in male Long Evans hooded rat o spring

  • Toxicology and Applied Pharmacology
  • 1997

Persistent suppression of delayed-type hypersensitivity (DTH) in rats perinatally exposed to TCDD

  • Toxicologist,
  • 1998