Construction of the N1-C3 linkage stereogenic centers by catalytic asymmetric amination reaction of 3-bromooxindoles with indolines.

Abstract

The catalytic asymmetric amination reaction of 3-bromooxindoles with indolines for the construction of the N1-C3 linkage stereogenic centers has been realized for the first time. Moreover, the racemic substrates (3-substituted indolines) were also applicable under the same chiral conditions. The newly developed method conveniently led to a formal synthesis of (+)-psychotrimine.

DOI: 10.1021/ol5007423

Cite this paper

@article{Zhang2014ConstructionOT, title={Construction of the N1-C3 linkage stereogenic centers by catalytic asymmetric amination reaction of 3-bromooxindoles with indolines.}, author={Hailong Zhang and Hong Seong Kang and Liang Hong and Weiping Dong and Guolin Li and Xin Zheng and Rui Wang}, journal={Organic letters}, year={2014}, volume={16 9}, pages={2394-7} }