Construction of sperm-specific lactate dehydrogenase DNA vaccine and experimental study of its immunocontraceptive effect on mice

@article{Chen2008ConstructionOS,
  title={Construction of sperm-specific lactate dehydrogenase DNA vaccine and experimental study of its immunocontraceptive effect on mice},
  author={Y. Chen and Duo Zhang and Na Xin and Y. Xiong and P. Chen and Bo Li and Xiang-dong Tu and F. Lan},
  journal={Science in China Series C: Life Sciences},
  year={2008},
  volume={51},
  pages={308-316}
}
Lactate dehydrogenase C4 (LDHC4) is a key enzyme for sperm metabolism. It is distributed specifically in testis and is highly immunogenic. In this study, two DNA vaccines pVAX1-hLDHC and pVAX1-mLDHC were constructed by inserting coding sequences of human and mice LDHC4 into the eukaryotic expression vector pVAX1. The production of LDHC4 specific antibodies was induced in the sera of vaccinated mice and the reproductive tract secretions of vaccinated female mice through immunization by mucosal… Expand
Immunogenicity Study of Plasmid DNA Encoding Mouse Cysteine‐Rich Secretory Protein‐1 (mCRISP1) as a Contraceptive Vaccine
Current knowledge of the human sperm proteome
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