Construction of skeletal myoblast-based polyurethane scaffolds for myocardial repair.

@article{Siepe2007ConstructionOS,
  title={Construction of skeletal myoblast-based polyurethane scaffolds for myocardial repair.},
  author={Matthias Siepe and M N Giraud and Elisabeth Liljensten and Urs E. Nydegger and Philippe Menasch{\'e} and Peter Wenaweser and Hendrik Tevaearai},
  journal={Artificial organs},
  year={2007},
  volume={31 6},
  pages={
          425-33
        }
}
Intramyocardial transplantation of skeletal myoblasts augments postinfarction cardiac function. However, poor survival of injected cells limits this therapy. It is hypothesized that implantation of myoblast-based scaffolds would result in greater cell survival. Rat skeletal myoblasts were seeded on highly porous polyurethane (PU) scaffolds (7.5 x 7.5 x 2.0 mm). The effect of several scaffold pretreatments, initial cell densities, and culture periods was tested by DNA-based cell count and… CONTINUE READING
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