Construction of protein-modified TiO2 nanoparticles for use with ultrasound irradiation in a novel cell injuring method.

@article{Ogino2010ConstructionOP,
  title={Construction of protein-modified TiO2 nanoparticles for use with ultrasound irradiation in a novel cell injuring method.},
  author={Chiaki Ogino and Naonori Shibata and Ryosuke Sasai and Keiko Takaki and Yusuke Miyachi and Shun-ichi Kuroda and Kazuaki Ninomiya and Nobuaki Shimizu},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 17},
  pages={5320-5}
}
Recently, our group discovered an alternative titanium dioxide (TiO(2)) activation method that uses ultrasound irradiation (US/TiO(2)) instead of ultraviolet irradiation. The pre-S1/S2 protein from hepatitis B virus, which recognizes liver cells, was immobilized to the surface of TiO(2) nanoparticles using an amino-coupling method. The ability of the protein-modified TiO(2) nanoparticles to recognize liver cells was confirmed by surface plasmon resonance analysis and immuno-staining analyses… CONTINUE READING

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