Construction of polyomavirus-derived pseudotype virus-like particles displaying a functionally active neutralizing antibody against hepatitis B virus surface antigen

@inproceedings{Pleckaityte2015ConstructionOP,
  title={Construction of polyomavirus-derived pseudotype virus-like particles displaying a functionally active neutralizing antibody against hepatitis B virus surface antigen},
  author={Milda Pleckaityte and Corinna M. Bremer and Alma Gedvilaite and Indrė Ku{\vc}inskaitė-Kodzė and Dieter Glebe and Aurelija Zvirbliene},
  booktitle={BMC biotechnology},
  year={2015}
}
BACKGROUND Virus-like particles (VLPs) can be efficiently produced by heterologous expression of viral structural proteins in yeast. Due to their repetitive structure, VLPs are extensively used for protein engineering and generation of chimeric VLPs with inserted foreign epitopes. Hamster polyomavirus VP1 represents a promising epitope carrier. However, insertion of large sized protein sequences may interfere with its self-assembly competence. The co-expression of polyomavirus capsid protein… CONTINUE READING
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