Construction of optically active indolines by formal [4+1] annulation of sulfur ylides and N-(ortho-chloromethyl)aryl amides.

Abstract

Get asymmetric! Asymmetric [4+1] annulation of sulfur ylides and N-(ortho-chloromethyl)aryl amides allowed the formation of the desired cycloadduct with moderate to high yields and enantioselectivities (see scheme). The described strategy, taking advantage of chiral sulfur ylides, represents a direct procedure to access chiral 2-substituted indolines.

DOI: 10.1002/chem.201300988

Cite this paper

@article{Yang2013ConstructionOO, title={Construction of optically active indolines by formal [4+1] annulation of sulfur ylides and N-(ortho-chloromethyl)aryl amides.}, author={Qing-qing Yang and Qiang Wang and Jing An and Jia-Rong Chen and Liang-Qiu Lu and Wen-Jing Xiao}, journal={Chemistry}, year={2013}, volume={19 26}, pages={8401-4} }