Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.

Abstract

New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.

DOI: 10.1021/ol402127b

Cite this paper

@article{Li2013ConstructionOM, title={Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.}, author={Dong Bo Li and Mark Rogers-Evans and Erick M Carreira}, journal={Organic letters}, year={2013}, volume={15 18}, pages={4766-9} }