Construction of microRNA functional families by a mixture model of position weight matrices

Abstract

MicroRNAs (miRNAs) are small regulatory molecules that repress the translational processes of their target genes by binding to their 3' untranslated regions (3' UTRs). Because the target genes are predominantly determined by their sequence complementarity to the miRNA seed regions (nucleotides 2-7) which are evolutionarily conserved, it is inferred that the… (More)
DOI: 10.7717/peerj.199

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