Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering.

@article{Xie2015ConstructionOL,
  title={Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering.},
  author={Wenping Xie and Xiaomei Lv and Lidan Ye and Pingping Zhou and Hongwei Yu},
  journal={Metabolic engineering},
  year={2015},
  volume={30},
  pages={69-78}
}
Improved supply of farnesyl diphosphate (FPP) is often considered as a typical strategy for engineering Saccharomyces cerevisiae towards efficient terpenoid production. However, in the engineered strains with enhanced precursor supply, the production of the target metabolite is often impeded by insufficient capacity of the heterologous terpenoid pathways, which limits further conversion of FPP. Here, we tried to assemble an unimpeded biosynthesis pathway by combining directed evolution and… CONTINUE READING
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