Construction of integrated microRNA and mRNA immune cell signatures to predict survival of patients with breast and ovarian cancer.

@article{Ray2019ConstructionOI,
  title={Construction of integrated microRNA and mRNA immune cell signatures to predict survival of patients with breast and ovarian cancer.},
  author={Mondira Ray and Matthew Ruffalo and Ziv Bar-Joseph},
  journal={Genes, chromosomes & cancer},
  year={2019},
  volume={58 1},
  pages={
          34-42
        }
}
In the tumor microenvironment, immune cells have emerged as key regulators of cancer progression. While much work has focused on characterizing tumor-related immune cells through gene expression profiling, microRNAs (miRNAs) have also been reported to regulate immune cells in the tumor microenvironment. Using regression-based computational methods, we have constructed for the first time, immune cell signatures based on miRNA expression from The Cancer Genome Atlas breast and ovarian cancer… CONTINUE READING
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