Construction of hybrid viruses containing SV40 and λ phage DNA segments and their propagation in cultured monkey cells

@article{Goff1976ConstructionOH,
  title={Construction of hybrid viruses containing SV40 and $\lambda$ phage DNA segments and their propagation in cultured monkey cells},
  author={S. Goff and P. Berg},
  journal={Cell},
  year={1976},
  volume={9},
  pages={695-705}
}
This paper describes the successful construction and propagation of a transducing animal virus. A segment of DNA approximately 2 kilobases (kb) in length was removed from the late region of the SV40 genome by sequential cleavages with Hpa II and Bam HI endonucleases (at 0.735 and 0.13, respectively, on the SV40 DNA map). A segment of about 1.5 kb of lambda phage containing ORI (the origin of lambda DNA replication), the two structural genes CII and cro, and four transcriptional promoters, was… Expand

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