Construction of designer glycoconjugate vaccines with size-specific oligosaccharide antigens and site-controlled coupling.

Abstract

Coupling of carbohydrate antigens to protein carriers is a typical approach to enhancing the immunogenicity of carbohydrate-based vaccines. Glycoconjugates with well-defined structures are needed for studies defining the structural variables that govern antibody responses. We report a chemical strategy for preparation of an array of glycoconjugates… (More)

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