Construction of an oncolytic herpes simplex virus that precisely targets hepatocellular carcinoma cells.

@article{Fu2012ConstructionOA,
  title={Construction of an oncolytic herpes simplex virus that precisely targets hepatocellular carcinoma cells.},
  author={Xinping Fu and Armando Rivera and Lihua Tao and Bart De Geest and Xiaoliu Zhang},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2012},
  volume={20 2},
  pages={339-46}
}
Selective replication in tumor cells is a highly desirable feature for oncolytic viruses. Recent studies have shown that microRNAs (miRNAs) play important roles in controlling gene expression, and that certain tissue-specific miRNAs are frequently downregulated in malignant cells. miR-122 is a liver-specific microRNA. It is abundantly expressed in normal hepatocytes but is absent in many hepatocellular carcinoma (HCC) cells. We hypothesized that expression of an essential viral gene by a liver… CONTINUE READING
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