Construction of an E. Coli genome-scale atom mapping model for MFA calculations.

@article{Ravikirthi2011ConstructionOA,
  title={Construction of an E. Coli genome-scale atom mapping model for MFA calculations.},
  author={Prabhasa Ravikirthi and Patrick F. Suthers and Costas D. Maranas},
  journal={Biotechnology and bioengineering},
  year={2011},
  volume={108 6},
  pages={
          1372-82
        }
}
Metabolic flux analysis (MFA) has so far been restricted to lumped networks lacking many important pathways, partly due to the difficulty in automatically generating isotope mapping matrices for genome-scale metabolic networks. Here we introduce a procedure that uses a compound matching algorithm based on the graph theoretical concept of pattern recognition along with relevant reaction information to automatically generate genome-scale atom mappings which trace the path of atoms from reactants… CONTINUE READING

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