Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).

@article{Wakefield1996ConstructionOA,
  title={Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).},
  author={John K. Wakefield and Sebyung Kang and Casey D. Morrow},
  journal={Journal of virology},
  year={1996},
  volume={70 2},
  pages={966-75}
}
The initiation of human immunodeficiency virus type 1 reverse transcription occurs by extension of a tRNA(Lys3) primer bound near the 5' end of the viral RNA genome which is designated the primer binding site (PBS). Sequences within the viral genome upstream of the PBS which are complementary to the anticodon loop (USUU) and the T psi C loop and arm (AGGGTm psi) of tRNA(Lys3) are postulated to play a role in maintaining the selective use of tRNA(Lys3) in reverse transcription. To investigate… CONTINUE READING

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