Construction of a single chain variable fragment antibody (scFv) against tetrodotoxin (TTX) and its interaction with TTX.

@article{Wang2014ConstructionOA,
  title={Construction of a single chain variable fragment antibody (scFv) against tetrodotoxin (TTX) and its interaction with TTX.},
  author={Rongzhi Wang and Ailing Huang and Licai Liu and Shuangshuang Xiang and Xiufeng Li and Sumei Ling and Lei Wang and Tun Lu and Shi-hua Wang},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2014},
  volume={83},
  pages={22-34}
}
Tetrodotoxin (TTX) is a small molecular weight neurotoxin that occludes voltage-gated sodium channels in nerve and muscle tissue, resulting in respiratory paralysis and death. A high affinity antibody that can neutralize the toxicity of TTX is still lacking, so it is very important to prepare an antibody for TTX therapy and detection. In the present study, a chemical method was used to prepare the tetrodotoxin complete antigen, and a small amount, repeatedly immunity way was carried to immunize… CONTINUE READING

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