Construction of a polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway.

@article{Oh2010ConstructionOA,
  title={Construction of a polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway.},
  author={Sangmi Oh and Hwan Jong Jang and Sung Kon Ko and Yeonjin Ko and Seung Bum Park},
  journal={Journal of combinatorial chemistry},
  year={2010},
  volume={12 4},
  pages={548-58}
}
In this study, a divergent and practical solid-phase parallel diversity-oriented synthesis (DOS) strategy was successfully applied for the construction of five discrete core skeletons embedded with privileged benzopyranyl substructure. The diversity of these core skeletons was expanded through the introduction of various substituents at the R, R(1), and R(2) positions from a single key intermediate in five different pathways. More importantly, we efficiently maximized the molecular diversity… CONTINUE READING