Construction of a novel scoring function by using a genetic algorithm for virtual screening of histone deacetylase inhibitors (HDACi)

Abstract

The comparison of different scoring functions on the discrimination and enrichment ability of histone deacetylase II (HDAC2) inhibitors were explored. A self-constructed database containing 45 inhibitors of HDAC2 and 2285 inactive compounds was performed screening study by using Surflex-Dock. The discrimination and enrichment ability of five scoring… (More)
DOI: 10.1109/ICNC.2013.6818014

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Cite this paper

@article{Xiang2013ConstructionOA, title={Construction of a novel scoring function by using a genetic algorithm for virtual screening of histone deacetylase inhibitors (HDACi)}, author={Yuhong Xiang and Yanbo Wei and Zhuoyong Zhang and Zhaoyan Hou}, journal={2013 Ninth International Conference on Natural Computation (ICNC)}, year={2013}, pages={428-433} }