Construction of a genetic toggle switch in Escherichia coli

@article{Gardner2000ConstructionOA,
  title={Construction of a genetic toggle switch in Escherichia coli},
  author={T. Gardner and C. Cantor and J. Collins},
  journal={Nature},
  year={2000},
  volume={403},
  pages={339-342}
}
It has been proposed that gene-regulatory circuits with virtually any desired property can be constructed from networks of simple regulatory elements. These properties, which include multistability and oscillations, have been found in specialized gene circuits such as the bacteriophage λ switch and the Cyanobacteria circadian oscillator. However, these behaviours have not been demonstrated in networks of non-specialized regulatory components. Here we present the construction of a genetic toggle… Expand
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