• Corpus ID: 6288852

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

@article{Botstein1980ConstructionOA,
  title={Construction of a genetic linkage map in man using restriction fragment length polymorphisms.},
  author={David Botstein and R L White and Mark H. Skolnick and R W Davis},
  journal={American journal of human genetics},
  year={1980},
  volume={32 3},
  pages={
          314-31
        }
}
We describe a new basis for the construction of a genetic linkage map of the human genome. The basic principle of the mapping scheme is to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests of an individual's DNA. Each of these probes will define a locus. Loci can be expanded or contracted to include more or less polymorphism by further application of recombinant DNA technology. Suitably… 
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