Construction of a doxycycline-dependent simian immunodeficiency virus reveals a nontranscriptional function of tat in viral replication.

@article{Das2007ConstructionOA,
  title={Construction of a doxycycline-dependent simian immunodeficiency virus reveals a nontranscriptional function of tat in viral replication.},
  author={Atze T. Das and Bep Klaver and Alex Harwig and Monique A Vink and Marcel Ooms and Mireille Centlivre and Ben Berkhout},
  journal={Journal of virology},
  year={2007},
  volume={81 20},
  pages={11159-69}
}
In the quest for an effective vaccine against human immunodeficiency virus (HIV), live attenuated virus vaccines have proven to be very effective in the experimental model system of simian immunodeficiency virus (SIV) in macaques. However, live attenuated HIV vaccines are considered unsafe for use in humans because the attenuated virus may accumulate genetic changes during persistence and evolve to a pathogenic variant. As an alternative approach, we earlier presented a conditionally live HIV-1… CONTINUE READING

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