Construction of a chromosome specific library of human MARs and mapping of matrix attachment regions on human chromosome 19.

Abstract

Using a novel procedure a representative human chromosome 19-specific library was constructed of short sequences, which bind preferentially to the nuclear matrix (matrix attachment regions, or MARs). Judging by 20 clones sequenced so far, the library contains > 50% of human inserts, about 90% of which are matrix-binding by the in vitro test. Computer… (More)

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@article{Nikolaev1996ConstructionOA, title={Construction of a chromosome specific library of human MARs and mapping of matrix attachment regions on human chromosome 19.}, author={Lev G. Nikolaev and T Tsevegiyn and Sergey B. Akopov and Linda Ashworth and Eugene D. Sverdlov}, journal={Nucleic acids research}, year={1996}, volume={24 7}, pages={1330-6} }