Construction of a Vertebrate Embryo from Two Opposing Morphogen Gradients

@article{Xu2014ConstructionOA,
  title={Construction of a Vertebrate Embryo from Two Opposing Morphogen Gradients},
  author={Peng-Fei Xu and Nathalie S. Houssin and Karine F. Ferri-Lagneau and Bernard Thisse and Christine Thisse},
  journal={Science},
  year={2014},
  volume={344},
  pages={87 - 89}
}
Designer Embryo Numerous signaling pathways have been implicated in controlling early vertebrate embryogenesis. P.-F. Xu et al. (p. 87) identify the minimal set of factors necessary to get uncommitted cells to organize a complete embryo. Two opposing gradients of the growth factors Nodal and Bone Morphogenetic Protein were sufficient to instruct zebrafish embryonic pluripotent cells to organize a complete embryo, not only in vivo but also in vitro. These findings may provide guidance for… 

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