Construction of a Computer Model to Investigate Sawtooth Effects in the Purkinje System

@article{Vigmond2007ConstructionOA,
  title={Construction of a Computer Model to Investigate Sawtooth Effects in the Purkinje System},
  author={Edward J. Vigmond and Clyde Clements},
  journal={IEEE Transactions on Biomedical Engineering},
  year={2007},
  volume={54},
  pages={389-399}
}
The sawtooth effect refers to how one end of a cardiac cell is depolarized, while the opposite end is hyperpolarized, upon exposure to an exogenous electric field. Although hypothesized, it has not been observed in tissue. The Purkinje system is a one-dimensional (1-D) cable-like system residing on the endocardial surface of the heart and is the most obvious candidate for the manifestation of this phenomenon. This paper describes a computer modeling study of the effect of electric fields on the… CONTINUE READING

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