Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence

  title={Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence},
  author={Stephan Gebel and Rosemarie B. Lichtner and Brian P Frushour and Walter K. Schlage and Vy Thuy Lynh Hoang and Marja Talikka and Arnd Hengstermann and Carole Mathis and Emilija Veljkovic and Michael John Peck and Manuel C. Peitsch and Renee Deehan and Julia Hoeng and Jurjen Willem Westra},
  booktitle={Bioinformatics and biology insights},
Towards the development of a systems biology-based risk assessment approach for environmental toxicants, including tobacco products in a systems toxicology setting such as the "21st Century Toxicology", we are building a series of computable biological network models specific to non-diseased pulmonary and cardiovascular cells/tissues which capture the molecular events that can be activated following exposure to environmental toxicants. Here we extend on previous work and report on the… CONTINUE READING
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