Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity.

@article{Page1990ConstructionAU,
  title={Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity.},
  author={Kimberly A. Page and Nathaniel R. Landau and Dan R. Littman},
  journal={Journal of virology},
  year={1990},
  volume={64 11},
  pages={5270-6}
}
We constructed a recombinant human immunodeficiency virus (HIV) vector to facilitate studies of virus infectivity. A drug resistance gene was inserted into a gp160- HIV proviral genome such that it could be packaged into HIV virions. The HIV genome was rendered replication defective by deletion of sequences encoding gp160 and insertion of a gpt gene with a simian virus 40 promoter at the deletion site. Cotransfection of the envelope-deficient genome with a gp160 expression vector resulted in… CONTINUE READING
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