Construction and initial characterization of a mouse-human chimeric anti-TNF antibody.

  title={Construction and initial characterization of a mouse-human chimeric anti-TNF antibody.},
  author={David M. Knight and Han Trinh and Junming Le and Stuart Siegel and David Shealy and Marie McDonough and Bernie Scallon and Malcolm A. S. Moore and Jan Vil{\vc}ek and Peter E. Daddona},
  journal={Molecular immunology},
  volume={30 16},
Tumor necrosis factor-alpha (TNF) has been implicated in the pathogenesis of a variety of human diseases including septic shock, cachexia, graft-versus-host disease and several autoimmune diseases. Monoclonal antibodies directed against TNF provide an attractive mode of therapeutic intervention in these diseases. We have generated a murine monoclonal antibody (A2) with high affinity and specificity for recombinant and natural human TNF. To increase its therapeutic usefulness, we used genetic… CONTINUE READING


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