Construction and immunogenicity of recombinant pseudorabies virus expressing the modified GP5m protein of porcine reproduction and respiratory syndrome virus

@article{Jiang2005ConstructionAI,
  title={Construction and immunogenicity of recombinant pseudorabies virus expressing the modified GP5m protein of porcine reproduction and respiratory syndrome virus},
  author={Yunbo Jiang and Liurong Fang and Shaobo Xiao and Hui Zhang and Huanchun Chen},
  journal={Frontiers of Biology in China},
  year={2005},
  volume={2},
  pages={85-91}
}
Pseudorabies virus (PRV), an alpha-herpesvirus, has been developed as a live viral vector for animal vaccines. However, the PRV recombinant virus TK−/gE−/GP5+ expressing GP5 of porcine reproductive and respiratory syndrome virus (PRRSV), based on the PRV genetically depleted vaccine strain TK−/gE−/LacZ+, scarcely stimulated the vaccinated animals to produce neutralizing antibodies against PRRSV. To develop a booster-specific immune response of such PRV recombinants, the ORF5m gene (the modified… CONTINUE READING

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