Construction and identification of recombinant adenovirus encoding TCF4 and ΔTCF4

@inproceedings{Huanxiang2013ConstructionAI,
  title={Construction and identification of recombinant adenovirus encoding TCF4 and ΔTCF4},
  author={Zhang Huan-xiang},
  year={2013}
}
Objective: To construct recombinant adenovirus encoding full-length T cell factor 4(TCF4) and a mutant TCF4(ΔTCF4),which delete the binding sites of β-catenin,and to investigate the expression and activity of these recombinant adenoviruses in MSCs,thereby providing the foundation for further study about the role of Wnt / β-catenin signaling in MSCs and sheding a light on the usefulness of MSCs in cell transplantation and gene therapies.Methods: The DNA sequences of TCF4 and ΔTCF4 were amplified… CONTINUE READING

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