Construction and evaluation of a novel recombinant T cell epitope-based vaccine against Coccidioidomycosis.

@article{Hurtgen2012ConstructionAE,
  title={Construction and evaluation of a novel recombinant T cell epitope-based vaccine against Coccidioidomycosis.},
  author={Brady J. Hurtgen and Chiung-Yu Hung and Gary R Ostroff and Stuart M Levitz and Garry T. Cole},
  journal={Infection and immunity},
  year={2012},
  volume={80 11},
  pages={3960-74}
}
Clinical and animal studies of coccidioidomycosis have demonstrated that activated CD4(+) T lymphocytes are essential for protection against this fungal respiratory disease. We previously reported a vaccine against Coccidioides infection which contained three recombinant CD4(+) T cell-reactive proteins and induced a robust, protective immune response in mice. Due to the anticipated high cost of production and clinical assessment of this multivalent vaccine, we generated a single protein which… CONTINUE READING