Construction and characterization of retroviral vectors for interleukin-2 gene therapy.

Abstract

Several investigators have employed interleukin-2 (IL-2) gene transfer to enhance the immunogenicity of tumor cell vaccines. We describe in this report the construction and characterization of retroviral vectors for IL-2 gene therapy. Human IL-2 cDNA with a chimeric rat preproinsulin/IL-2 DNA leader sequence was subcloned into the pLXSN (long terminal… (More)

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@article{Fakhrai1997ConstructionAC, title={Construction and characterization of retroviral vectors for interleukin-2 gene therapy.}, author={Habib Fakhrai and Daniel L. Shawler and Charles Van Beveren and H Lin and Oliver Dorigo and Matthew J Solomon and Ruth A. Gjerset and Lorraine Smith and Richard M. Bartholomew and Carolina Boggiano and Daniel P. Gold and Robert E. Sobol}, journal={Journal of immunotherapy}, year={1997}, volume={20 6}, pages={437-48} }