Construction and characterization of mutations within the Klebsiella mrkD1P gene that affect binding to collagen type V.

@article{Sebghati1999ConstructionAC,
  title={Construction and characterization of mutations within the Klebsiella mrkD1P gene that affect binding to collagen type V.},
  author={Tricia Ann Schurtz Sebghati and Steven Clegg},
  journal={Infection and immunity},
  year={1999},
  volume={67 4},
  pages={
          1672-6
        }
}
The fimbria-associated MrkD1P protein mediates adherence of type 3 fimbriate strains of Klebsiella pneumoniae to collagen type V. Currently, three different MrkD adhesins have been described in Klebsiella species, and each possesses a distinctive binding pattern. Therefore, the binding abilities of mutants possessing defined mutations within the mrkD1P gene were examined in order to determine whether specific regions of the adhesin molecule were responsible for collagen binding. Both site… CONTINUE READING

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