Construction and characterization of a recombinant herpes simplex virus type 1 which overexpresses the transrepressor protein ICPOR.

ICPOR is a truncated form of the herpes simplex virus type 1 (HSV-1) transactivator protein ICPO that is synthesized at low levels during infection through an alternative splicing mechanism. In transient expression assays, ICPOR has been shown to inhibit the transactivation function of several HSV-1 regulatory proteins, suggesting that an antiviral strategy… (More)