Construction and characterization of Marek's disease viruses having green fluorescent protein expression tied directly or indirectly to phosphoprotein 38 expression.

@article{Prigge2004ConstructionAC,
  title={Construction and characterization of Marek's disease viruses having green fluorescent protein expression tied directly or indirectly to phosphoprotein 38 expression.},
  author={Jon T Prigge and Vladimir Majerciak and Henry D. Hunt and Robert L. Dienglewicz and Mark S Parcells},
  journal={Avian diseases},
  year={2004},
  volume={48 3},
  pages={471-87}
}
Marek's disease (MD) is caused by Marek's disease virus (MDV), a highly cell-associated alphaherpesvirus. MD is primarily characterized by lymphocyte infiltration of the nerves and the development of lymphomas in visceral organs, muscle, and skin. MDV encodes two phosphoproteins, pp24 and pp38, that are highly expressed during lytic infection. These proteins were initially identified in MDV-induced tumors but are now known to be linked primarily to MDV lytic infection. Despite the recent… CONTINUE READING