Construction and Immunogenic Characterization of a Fusion Anti-caries DNA Vaccine against PAc and Glucosyltransferase I of Streptococcus mutans

  title={Construction and Immunogenic Characterization of a Fusion Anti-caries DNA Vaccine against PAc and Glucosyltransferase I of Streptococcus mutans},
  author={J H Guo and Rong Jia and Ming Wen Fan and Zhuan Bian and Z Chen and Bin Peng},
  journal={Journal of Dental Research},
  pages={266 - 270}
  • J. Guo, R. Jia, B. Peng
  • Published 1 March 2004
  • Biology, Medicine
  • Journal of Dental Research
Glucosyltransferases (GTFs) and A cell-surface protein (PAc) are two important virulence factors of the cariogenic organism Streptococcus mutans. They may mediate sucrose-independent or sucrose-dependent attachment of Streptococcus mutans to tooth surfaces, respectively. Thus, inhibiting both virulence factors is predicted to provide better protection against caries than inhibiting a single factor. To develop a highly efficient vaccine against caries, we constructed a fusion DNA vaccine, pGLUA… 

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    Current opinion in dentistry
  • 1992
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