Construction and Evaluation of V. cholerae O139 Mutant, VCUSM21P, as a Safe Live Attenuated Cholera Vaccine

@inproceedings{Murugaiah2014ConstructionAE,
  title={Construction and Evaluation of V. cholerae O139 Mutant, VCUSM21P, as a Safe Live Attenuated Cholera Vaccine},
  author={Chandrika Murugaiah and Nik Zuraina Nik Mohd Noor and Shyamoli Mustafa and Ravichandran Manickam and Lalitha Pattabhiraman},
  booktitle={PloS one},
  year={2014}
}
Cholera is a major infectious disease, affecting millions of lives annually. In endemic areas, implementation of vaccination strategy against cholera is vital. As the use of safer live vaccine that can induce protective immunity against Vibrio cholerae O139 infection is a promising approach for immunization, we have designed VCUSM21P, an oral cholera vaccine candidate, which has ctxA that encodes A subunit of ctx and mutated rtxA/C, ace and zot mutations. VCUSM21P was found not to disassemble… CONTINUE READING
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